The Curi Bio Mantarray platform enables the discovery, safety, and efficacy testing of new therapeutics by providing parallel analysis of 3D engineered muscle tissues with adult-like functional profiles. Mantarray brings clinically-relevant functional data into the earliest stages of preclinical testing of new medicines.
Features
- High-throughput compatible, label-free, non-optical measurement
- Clinically-relevant functional measurements of contractility
- Easy tissue casting, measurement, and data analysis (No Matlab, All GUI)
- Structurally and functionally mature 3D engineered muscle tissues
- Compatible with electrical stimulation for advanced tissue maturation
Application
Disease Modeling & Therapeutic Discovery
Modeling Duchenne Muscular Dystrophy (DMD) with iPSC-derived EHTs
Complex diseases require complex models. EMTs can be made from cells sourced from patients and used to test whether a new therapy will improve or recover healthy contraction. 3D Engineered Heart Tissues (EHTs) can be generated from human iPSC-derived cells with healthy and diseased phenotypes.
Multi-modal Mantarray Data Exhibit Disease Stratification
Isogenic controls or corrected cell lines can be used to provide clear stratification between healthy and diseased phenotypes. Stratifying differences between healthy disease model EHTs provides a platform for discovery and validation of new therapeutics. Validate new therapies using human models of muscle contractility.
Application
Safety Screening
Magnetic Detection of Drug-induced Contractile Changes
The magnetic detection approach can measure both acute (minutes) and chronic (days) drug responses. Drugs such as isoproterenol (left) can be measured on the order of seconds to minutes, with enough sensitivity to measure dose response-like behavior. Additionally, longer-term chronic experiments such as doxorubicin (right) can be performed over the course of days.How It Works
The Mantarray system features a novel magnetic sensing technique that can detect the contraction of EMTs. This enables the user to measure the contractility of 24 tissues in parallel, a high throughput, and in real time. The system features user-friendly software that takes away the requirement for manual calculations of contractility, delivering contractility data at the click of a mouse.
The Mantarray system uses ANSI/SLAS compliant tissue casting devices that can be performed manually or via automation. EMTs can be used in nearly any kind of assay, including force (contractility), calcium, and structural assays. Mantarray brings EMTs into your own lab, allowing you to use your own cells to achieve your research goals.
Early Access Product
Curi Bio's Mantarray System:
Bring 3D Engineered Heart Tissues into Your Laboratory
Be among the first to receive an instrument. Learn more today.
Download Mantarray brochure here.