The LCI Bio QUADSCAN is an advanced confocal imaging system that integrates a high-speed confocal unit, a motorized microscope, and powerful software into a single, streamlined platform.
Whether for live-cell imaging, time-lapse experiments, or high-resolution fluorescence analysis, QUADSCAN provide reliable and accurate biological results through advanced imaging technology, supporting high-quality experimental analysis.
Features
All-in-one structural module for each channel: QUADSCAN has a unique subunit structure which contains all the necessary components for each fluorescence band excitation and detection in a single unit. QUADSCAN supports single channel observation as well as up to four multi-channel (405 nm, 488 nm, 561 nm, and 638 nm) simultaneous excitation and observation
High-sensitivity detectors: By employing the world’s most sensitive detector (photomultiplier tube) and applying our signal processing know-how, it enables highly sensitive detection of fluorescence signals. This sensitivity is critical for enhancing signal-to-noise ratio in fluorescence imaging and expanding its applications across various biological fields.
QUADSCAN is mounted via a side port of the inverted microscope
with a C-mount TV adapter.
High-speed scanning with MEMS mirror: We adopted our 29 kHz resonant type high-speed MEMS* mirror as a spot scanning device. The MEMS mirror allows for a high-speed scan up to 76 frames/s and can be used for high-speed phenomena such as Ca dynamics. The high-speed resonant scanning system reduces laser irradiation time, which enables low phototoxicity, low photobleaching and high-efficiency observation of live cells as well as fixed samples. High-speed scanning allows for comfortable observation at high resolution with minimal display delay when searching for or focusing on samples.
* MEMS = Micro-Electro-Mechanical Systems
Conventional confocal optics: QUADSCAN was designed to comply to the conventional confocal optics, which has a long history, using a spot scanning device and pinholes to acquire optical sectioning images. When imaging thick fluorescence samples, only the fluorescence emitted from the focal plane of the objective passes through the pinholes to the detector, while fluorescence emitted from further away from the focal plane is blocked. It detects quantitative, reproducible and reliable signals. It also acquires high contrast images without the need for image processing techniques, such as deconvolution
Sample: Mouse kidney section: QUADSCAN detects fluorescence in the objective focal plane only, so high contrast optical sectioning images can be acquired.
Stable and highly scalable live cell imaging platform: QUADSCAN provides an advanced imaging platform with 25mm field of view, to meet experimental needs of large flux observation. Full-motorized QUADSCAN realize integration of multimodal imaging technology. Anti-focus shift module can be optional which is more suitable for long-time dynamic imaging of living cells. QUADSCAN provides stable and reliable platform for confocal.
In addition, the touch screen could achieve smooth control of electric components while recording status of each sensor, recording user usage habits, switch application scene by one-click. Combined with powerful acquisition and analysis software, QUADSCAN is full of stability and scalability, meet a variety of experimental needs, provide reliable, repeatable data.
Incomparable 25mm field of view: With the research trend towards large-scale, high-flux and intelligent solutions, demand for faster data acquisition and higher throughput is increasing day by day. No matter it is bright field imaging or fluorescence imaging, QUADSCAN large-area illuminator and large-field fluorescence attachment provides uniform and bright cell imaging. Large size sensors and imaging interfaces that truly maximize performance of large format detector and provide perfect imaging platform for the future as camera technology continues to evolve rapidly.
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