Rapid Immunostaining with Unparalleled Uniformity.
End-of-year SmartClear II Pro + SmartLabel bundle discount: Get both devices in your lab with a 25% discount!
Request a quote today and claim your end-of-year discount on SmartClear II Pro and SmartLabel. Don't wait, this deal only lasts through the end of December!
LifeCanvas Technologies' SmartLabel, the world’s first active labeling device, combines SWITCH and stochastic electrotransport technologies to quickly and uniformly label whole tissue samples in a fraction of the time needed for passive labeling. Stain an entire mouse brain or rat hemisphere in 24 hours or less and avoid the time-intensive, destructive sectioning and tedious image reconstruction of traditional histology.
Fast: Label large, intact samples such as rodent organs an order of magnitude faster than with passive labeling (≤ 24 hours vs. weeks to months).
Easy: Turnkey operation – simply load the buffers and your sample & probes. Perform 2 distinct labeling experiments simultaneously thanks to SmartLabel’s dual chamber design.
Efficient: Uses a small amount of antibody (as little as ~3 µg) to label tissues the size of a whole mouse brain.
Reliable: Prevents tissue damage with Stochastic Electrotransport technology (Kim, PNAS, 2015). Our nanoporous membranes (patent-pending) eliminate tissue contamination and probe loss.
With SmartClear II Pro and SmartLabel, you can clear whole mouse brains in 4-5 days, immunolabel intact samples in 1-2 days rather than weeks of passive labeling, and produce stunning, reproducible, insight-rich data ready for publication.
Complete and Uniform Labeling
- Achieves unparalleled uniformity of signal intensity from surface to core using LifeCanvas’s advanced eFLASH (Yun, bioRxiv, 2019) protocol.
- Combines rapid, Stochastic Electrotransport-mediated (Kim, PNAS, 2015) infiltration of probes into tissue with the SWITCH technique (Murray, Cell, 2015) of controlling probe binding kinetics.
Cost Savings by Avoiding Target Saturation
- Prevents antibody depletion caused by excessive binding to superficial tissue sites and ensures the sample’s center is well-labeled.
Compatible with Many Cleared-Tissue Techniques
- SHIELD (Park, Nature Biotechnology, 2018)
- MAP (Ku, Nature Biotechnology, 2016)
- SWITCH (Murray, Cell, 2015)
Download SmartLabel brochure here.
Anti-GFAP Staining in CA1 Hippocampus of 2-mm Thick Section of Mouse Brain
Volume rendering of anti-GFAP staining in a 2-mm thick section of mouse brain, with signal in CA1 hippocampus most prominent. Labeling achieved in 2 days using antibody electrophoresis performed by SmartLabel. Cleared with SmartClear II Pro (<1 day), refractive index-matched with EasyIndex, and light-sheet imaged with SmartSPIM (<4 minutes acquisition time with 2-µm z-step and 1.8 µm/pixel XY; 2×2 tile using a 3.6x, 0.2 NA objective). See more videos in the Life Canvas Technologies video gallery.