Biomimetic Nanoscale Surface Topography Imitates the Aligned Structure of the Native Extracellular Matrix.

NanoSurface Biomedical provides innovative products and services for drug development, disease modeling, and fundamental research into cell biology. NanoSurface technology imitates the native extracellular matrix and structures cultured cells into physiologically relevant models.

Cells in the Dish Should Resemble Cells in the Body.

Human iPSC-derived cardiomyocytes cultured in a NanoSurface dish develop structural and functional phenotypes similar to native cardiac tissue. NanoSurface culture is consistent, reproducible, and fast, which is why many scientists rely on NanoSurface technology as a new standard for iPSC-derived cardiomyocyte culture.

(CDI iCell) Conventional Dish (CDI iCell) NanoSurface Cultureware

More Mature Cell and Tissue Cultures, Faster

NanoSurface Cultureware provides your cells and tissues a biomimetic surface to improve the physiological relevance of your experiments. Shortly after plating, cells cultured on NanoSurface Cultureware exhibit enhanced structural and phenotypic development when compared to cells grown on conventional dishes. NanoSurface topography promotes cytoskeletal reorganization, cellular alignment, and functional development. NanoSurface Cultureware is available in familiar standard formats, featuring No. 1.5 glass-bottom wells for high-quality imaging. 

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Benefits of NanoSurface Cultureware

  • High-quality Imaging
  • Compatible with high-magnification, high-NA transmitted light and fluorescence microscopy techniques. No spectral loss across commonly used fluorophores.
  • Reproducibly Structured Cell Cultures
  • Highly uniform, precise, and accurate nanopatterns ensure that your results are consistent from plate to plate.
  • Industry Standard Culture Formats
  • Cultureware comes in a variety of ANSI/SLAS compliant form factors to guarantee compatibility with existing instrumentation and hardware. 
  • Biomimetic Technology
  • Nanoscale topography mimics the aligned architecture of the extracellular matrix. 
  • NanoSurface Dishes Promote the Structural and Phenotypic Development of Many Cell Types

 

Examples of cells cultures that would benefit with the use of NanoSurface Cultureware:

  • Fibroblasts
  • Cancer cells
  • Induced pluripotent stem cells
  • Mesenchymal stem cells
  • Human embryonic stem cells
  • Skeletal muscle cells
  • Smooth muscle cells
  • Neuronal cells
  • Cardiomyocytes
  • Endothelial cells
  • Epithelial cells
  • And many more

Conventional Dish

Conventional cultureware does not utilize biomimetic surface topography, which results in random structural orientation. The disorganized isotropic cell and tissue architectures result in immature functional phenotypes that do not reproduce in vivo function. These inaccuracies lead to imprecise, hard-to-reproduce results and wasted time and effort.

EA.hy926 Human Endothelial Cells / Conventional EA.hy926 Human Endothelial Cells / NanoSurface

NanoSurface Cultureware

NanoSurface Cultureware features a nanopatterned culture surface which provides a cellular microenvironment that mimics the aligned architecture of the native extracellular matrix – improving physiological relevance by promoting development. Cells can align, elongate, grow, and even migrate along the pattern while exhibiting more physiologically representative structural and functional phenotypes. 

Biomimetic Nanoscale Surface Topography Imitates the Aligned Structure of the Native ECM

Nanopatterned culture surfaces allow cells to align, elongate, grow, and even migrate along the nanopattern while exhibiting more physiologically representative structural and functional phenotypes.

 

The underlying matrix of the native myocardium has an aligned architecture (scale bar 10 µm).

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